The goal of the CRC 1160
The Collaborative Research Center (CRC) 1160. “Immune-mediated pathology as a consequence of impaired immune reactions (IMPATH)” is a research consortium of clinical and basic immunologists exploring the basis of diseases mediated by the immune system.
The CRC sets out to challenge the traditional idea that an “overreaction” or “deviation“ of normal immune responses is pivotal to immune mediated pathology and that, consequently, immunosuppression is the appropriate therapeutic strategy for such disorders. Instead, the conceptual basis of the CRC is the idea that impaired immune reactions constitute a major prerequisite for immunopathology. This is what we call the “IMPATH paradox”. This paradox implies that immune reconstitution and/or immune stimulation rather than immunosuppression represent appropriate therapeutic principles for these forms of immunopathology.
News
Publications
Zwick M, Zinkel B, Spohr C, Rückert T, Halbach S, Shoumariyeh K, Scheid J, Baur AS, Braun LM, Angel M, Michaeli E, Todkar A, Nelde A, Märklin M, Holzmayer SJ, Dicks S, Boerries M, Duquesne S, Schlaak AE, Otto-Mora P, Bengsch B, Schiff M, Kissel S, Selle M, Follo M, Altmann H, Kunadt D, Illert AL, Walz JS, Walz G, Duyster J, Schetelig J, Brummer T, Zeiser R, Köhler N. 2025. FLT3-ITD Induces CMTM6 and Enhances Immune Escape in Acute Myeloid Leukemia. Cancer Res. Oct 3. doi: 10.1158/0008-5472.CAN-25-0349.
Gres V, Göcer M, Kolter J, Henneke P. 2025. Trained immunity in skin infections: Macrophages and beyond. Elife. 14:e106688. doi: 10.7554/eLife.106688.
Bendl E, Lampo G, Chlanda P, Schnettler E, Kochs G, Dengjel J, Graf L. 2025. A novel accessory gene product of tick-borne Dhori-Orthomyxovirus, encoded by overlooked spliced transcripts of RNA segment 6. J Virol. 2025 Sep 15:e0060025. doi: 10.1128/jvi.00600-25.
Epting D, Devane J, Mertes R, Kayser S, Helmstädter M, Metzger P, Boerries M, Bergmann C, Ott E. 2025. Tulp3 deficiency results in ciliopathy phenotypes during zebrafish embryogenesis. Sci Rep. 15(1):32435. doi: 10.1038/s41598-025-16584-3.
Petry P, Oschwald A, Merkt S, Dinh TJ, Andrieux G, Crisand C, Botterer H, Nent E, Paterson N, Havermans M, Sankowski R, Schilling O, Boerries M, Amann L, Groß O, Schlitzer A, Prinz M, Lämmermann T, Kierdorf K. 2025. Early microglia progenitors colonize the embryonic CNS via integrin-mediated migration from the pial surface. Dev Cell. S1534-5807(25)00532-5. doi: 10.1016/j.devcel.2025.08.012.
Contact
Scientific Manager/Administration
Dr. Heike Ufheil
Institute for Immunodeficiency (IFI),
Center for Chronic Immunodeficiency (CCI)
Medical Center – University of Freiburg
