The goal of the CRC 1160
The Collaborative Research Center (CRC) 1160. “Immune-mediated pathology as a consequence of impaired immune reactions (IMPATH)” is a research consortium of clinical and basic immunologists exploring the basis of diseases mediated by the immune system.
The CRC sets out to challenge the traditional idea that an “overreaction” or “deviation“ of normal immune responses is pivotal to immune mediated pathology and that, consequently, immunosuppression is the appropriate therapeutic strategy for such disorders. Instead, the conceptual basis of the CRC is the idea that impaired immune reactions constitute a major prerequisite for immunopathology. This is what we call the “IMPATH paradox”. This paradox implies that immune reconstitution and/or immune stimulation rather than immunosuppression represent appropriate therapeutic principles for these forms of immunopathology.
News
Publications
Osborn MJ, Panda S, Reineke TM, Tolar J, Nyström A. 2025. Progress in skin gene therapy: From the inside and out. Mol Ther. Mar 12:S1525-0016(25)00191-1. doi: 10.1016/j.ymthe.2025.03.017.
Geiger RA, Khera D, Tenthorey JL, Kochs G, Graf L, Emerman M, Malik HS. 2025. Heterozygous and generalist MxA super-restrictors overcome breadth-specificity trade-offs in antiviral restriction. Sci Adv. May 2;11(18):eadu0062. doi: 10.1126/sciadv.adu0062.
Wess M, Rogg M, Gueib-Picard C, Merz A, Kössinger AL, Feilen T, Andreev G, Werner M, Frew IJ, Grabbert M, Schilling O, Schell C. 2025. Versatile roles of annexin A4 in clear cell renal cell carcinoma: Impact on membrane repair, transcriptional signatures, and composition of the tumor microenvironment. iScience. 28(4):112198. doi: 10.1016/j.isci.2025.112198.
Arp AB, Abel Gutierrez A, Ter Beest M, Franken GA, Warner H, Rodgers Furones A, Kenyon AN, Jäger F, Cabrera-Orefice A, Kläsener K, van Deventer S, Droesen L, Dunlock VME, Classens R, Staniek J, Borst J, Reth M, Brandt U, Gros P, Kuijpers TW, Heemskerk MHM, Rizzi M, Querol Cano L, van Spriel AB. 2025. CD70 recruitment to the immunological synapse is dependent on CD20 in B cells. Proc Natl Acad Sci U S A. 122(16):e2414002122. doi: 10.1073/pnas.2414002122.
Röttele F, Zollner A, Mogler C, Yuksel M, Arikan C, Karl V, Aberle JH, Aberle SW, Kogler H, Vécsei A, Vodopiutz J, Salié H, Gräser A, Krimmel L, Martin P, Lurz E, Maier FI, Woelfle L, Nobre S, Goncalves I, Kern L, Schwemmle M, Boettler T, Hofmann M, Hasselblatt P, Thimme R, Tilg H, Müller T, Vogel GF, Bengsch B. 2025. Characteristic immune cell interactions in livers of children with acute hepatitis revealed by spatial single-cell analysis identify a possible postacute sequel of COVID-19. Gut. Apr 5:gutjnl-2024-333880. doi: 10.1136/gutjnl-2024-333880.
Contact
Scientific Manager/Administration
Dr. Heike Ufheil
Institute for Immunodeficiency (IFI),
Center for Chronic Immunodeficiency (CCI)
Medical Center – University of Freiburg
