Projects

Project Area A: Impaired T cell functions resulting in immunopathology

A01
  • Prof. Dr. Stephan Ehl
  • Dr. Peter Aichele
Genetic defects impairing lymphocyte cytotoxicity: causes and consequences
A02
  • Prof. Dr. Maike Hofmann
  • Prof. Dr. Robert Thimme
Diverging mechanisms of virus-specific CD8 T cell dysfunction result in protective versus pathogenic responses in chronic hepatitis B virus infection
A03
  • Prof. Dr. Dr. Bertram Bengsch
Pathogenic instruction of CD8 T cell differentiation in Crohn's disease
A06
  • Prof. Dr. Christoph Neumann-Haefelin
Mechanisms of hepatitis E virus persistence and immunopathology in immunocompromised patients
A08N
  • Dr. Maria Elena Maccari
  • Dr. Anne Rensing-Ehl
Lymphoproliferative disease resulting from impaired deletion of FAS controlled T cells

Project Area B: Signals and cells regulating immunopathology

B01
  • Prof. Dr. Susana Minguet
Caveolin-1 and Filamin A: a novel mechanistic axis regulating B cell responses and immunopathology
B02
  • Prof. Dr. Marta Rizzi
Autoimmunity because of defective B cell fate decisions in autoimmune lymphoproliferative syndrome
B03
  • Prof. Dr. Dimitra Kiritsi
  • PD Dr. Alexander Nyström
Immune-mediated pathology as a consequence of impaired lymphocyte-extracellular matrix interactions
B05
  • Prof. Dr. Bodo Grimbacher
Studying the intestinal microbiome as a driver for immune pathology in CTLA4 insufficient individuals and mice
B08
  • Dr. Sagar
  • Dr. Yakup Tanriver
Bi-directional communication between intraepithelial lymphocytes and epithelial cells to maintain intestinal barrier integrity
B09
  • Jun.-Prof. Dr. Natalie Köhler
  • Prof. Dr. Robert Zeiser
Overcoming intestinal immune dysregulation by metabolic modification during acute graft-versus-host-disease
B10N
  • Prof. Dr. Stephan Rosshart
  • Prof. Dr. Robert Zeiser
Impact of wild-type intestinal microbiome on impaired immune regulation during acute graft-versus-host disease

Project Area C: Impaired macrophage homeostasis resulting in immunopathology

C01
  • Dr. Laura Graf
  • Prof. Dr. Martin Schwemmle
Immunopathology resulting from lack of early control of influenza virus infection by interferon-induced Mx proteins: causes and consequences
C02
  • Prof. Dr. Olaf Groß
GM-CSF-induced impairment of macrophage homeostasis resulting in lung immunopathology
C03
  • Prof. Dr. Marco Prinz
Mapping cellular interactions of human tissue macrophages during health and immune-mediated pathologies by spatial proteogenomics
C05N
  • Jun.-Prof. Dr. Katrin Kierdorf
CTSD-deficiency in macrophages links impaired lysosomal function to immune-mediated pathology across different organs
C06N
  • Prof. Dr. Philipp Henneke
Macrophage dysregulation as cause of chronic inflammation in NADPH oxidase deficiency

Associated Projects

AI01
  • Dr. Oleg Borisov
  • Dr. Oliver Wegehaupt
Genetic variants in cytotoxicity-related genes in the pathogenesis of familial hemophagocytic histiocytosis (HLH)

Central Projects

Z01
  • Prof. Dr. Dr. Christoph Schell
  • Prof. Dr. Dr. Bertram Bengsch
Immunopathology Unit
Z02
  • Prof. Dr. Dr. Melanie Börries
  • Dr. Sagar
Bioinformatics Core
INF(N)
  • Prof. Dr. Harald Binder
Information infrastructure for research data management

Contact

Scientific Manager/Administration
Dr. Heike Ufheil
Institute for Immunodeficiency,
Center for Chronic Immunodeficiency (CCI)
Medical Center – University of Freiburg

+49 (0) 761 / 270-71020 info@sfb1160.uni-freiburg.de
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