The goal of the CRC 1160
The Collaborative Research Center (CRC) 1160. “Immune-mediated pathology as a consequence of impaired immune reactions (IMPATH)” is a research consortium of clinical and basic immunologists exploring the basis of diseases mediated by the immune system.
The CRC sets out to challenge the traditional idea that an “overreaction” or “deviation“ of normal immune responses is pivotal to immune mediated pathology and that, consequently, immunosuppression is the appropriate therapeutic strategy for such disorders. Instead, the conceptual basis of the CRC is the idea that impaired immune reactions constitute a major prerequisite for immunopathology. This is what we call the “IMPATH paradox”. This paradox implies that immune reconstitution and/or immune stimulation rather than immunosuppression represent appropriate therapeutic principles for these forms of immunopathology.
News
Landesforschungspreis Baden-Württemberg für Angewandte Forschung for Scientist of CRC 1160
Feb 27, 2026 –
Prof. Dr. Robert Zeiser, principal investigator of CRC 1160 (B09, B10), has been awarded the Landesforschungspreis Baden-Württemberg für Angewandte Forschung for his pioneering work in cancer medicine.
Publications
Engel, F., Giuliani, C., Watter, M., Kalantari, A., Schuller, K., Binder, H., & Kaier, K. 2026. From manual entry to machine precision: Challenges and evolution of metadata schema development in collaborative research centers. BMC Research Notes 19(1), 277. https://doi.org/10.1186/s13104-026-07937-w
Polcik L, Pethe A, Ashok D, Tissino E, Fernández-Rego A, Pozzo F, Danner DJ, Holst M, Martines C, Hofmann K, Dimovski AJ, Kissel S, Härzschel A, Li L, Bittolo T, Andrieux G, Haslauer T, Höpner JP, Zaborsky N, Greil R, Miething C, Duque-Afonso J, Köhler N, Boerries M, Bomben R, Duyster J, Grosse R, Gaidano G, Zamò A, Zucchetto A, Carrasco YR, Efremov DG, Gattei V, Hartmann TN. 2026. CD49d governs immune synapse formation through actin rearrangements and synchronizes BCR signaling in CLL. Blood. 2026 Jun 25;147(26):3179-3194. doi: 10.1182/blood.2024027753.
Sindram E, Montero-Hernández JE, Frenger Q, van Dijk H, Lang A, Zeidler V, Marsiske R, Rhiel M, Geiger K, Cornu TI, Mace EM, Spindler V, Dengjel J, Gros F, Grimbacher B, Sepulveda FE, Carrasco YR, Andreani V, Gámez-Díaz L. 2026. LRBA regulates actin cytoskeleton dynamics through NMIIA during B cell immune responses. EMBO Rep. Jun 12. doi: 10.1038/s44319-026-00831-3.
Boettler T, Neumann-Haefelin C. 2026. Hepatitis B immunoglobulins after liver transplantation: essential early, optional later? Gut. Jun 11:gutjnl-2026-339122. doi: 10.1136/gutjnl-2026-339122.
Döring CL, Henneke P, Kolter J. 2026. TGF-β: A master regulator of tissue-resident macrophage identity and function. Trends Immunol. Jun 9:S1471-4906(26)00128-6. doi: 10.1016/j.it.2026.05.003.
Contact
Scientific Manager/Administration
Dr. Heike Ufheil
Institute for Immunodeficiency (IFI),
Center for Chronic Immunodeficiency (CCI)
Medical Center – University of Freiburg
