Frederike Hartl

2012 – 2016	PhD student in the lab of Prof. Wolfgang Schamel, AG Dr. Susana Minguet, Institute of Biology II/III, BIOSS Signalhaus, University of Freiburg
2006 – 2012	Study of Biology, University of Freiburg, Germany

Publications

Swamy, M., K. Beck-Garcia, E. Beck-Garcia, F. A. Hartl, A. Morath, O. S. Yousefi, E. P. Dopfer, E. Molnar, A. K. Schulze, R. Blanco, A. Borroto, N. Martin-Blanco, B. Alarcon, T. Hofer, S. Minguet, and W. W. Schamel. 2016. A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation. Immunity 44: 1091-1101.

Schonle, A.*, F. A. Hartl*, J. Mentzel, T. Noltner, K. S. Rauch, A. Prestipino, S. A. Wohlfeil, P. Apostolova, A. K. Hechinger, W. Melchinger, K. Fehrenbach, M. C. Guadamillas, M. Follo, G. Prinz, A. K. Ruess, D. Pfeifer, M. Angel Del Pozo, A. Schmitt-Graeff, J. Duyster, K. I. Hippen, B. R. Blazar, K. Schachtrup, S. Minguet, and R. Zeiser. 2016. Caveolin-1 regulates TCR signal strength and regulatory T-cell differentiation into alloreactive T cells. Blood 127: 1930-1939. *equal contribution

Paensuwan, P., F. A. Hartl, O. S. Yousefi, J. Ngoenkam, P. Wipa, E. Beck-Garcia, E. P. Dopfer, B. Khamsri, D. Sanguansermsri, S. Minguet, W. W. Schamel, and S. Pongcharoen. 2016. Nck Binds to the T Cell Antigen Receptor Using Its SH3.1 and SH2 Domains in a Cooperative Manner, Promoting TCR Functioning. J Immunol 196: 448-458.

Paensuwan, P., F. A. Hartl, O. S. Yousefi, J. Ngoenkam, P. Wipa, E. Beck-Garcia, E. P. Dopfer, B. Khamsri, D. Sanguansermsri, S. Minguet, W. W. Schamel, and S. Pongcharoen. 2016. Correction: Nck Binds to the T Cell Antigen Receptor Using Its SH3.1 and SH2 Domains in a Cooperative Manner, Promoting TCR Functioning. J Immunol 196: 4833.

Dopfer, E. P., F. A. Hartl, H. H. Oberg, G. M. Siegers, O. S. Yousefi, S. Kock, G. J. Fiala, B. Garcillan, A. Sandstrom, B. Alarcon, J. R. Regueiro, D. Kabelitz, E. J. Adams, S. Minguet, D. Wesch, P. Fisch, and W. W. Schamel. 2014. The CD3 conformational change in the gammadelta T cell receptor is not triggered by antigens but can be enforced to enhance tumor killing. Cell Rep 7: 1704-1715.

Publications based on CRC1160 funding

Woessner NM, Brandl SM, Hartmann S, Schamel WW, Hartl FA, Minguet S. 2024. Phospho-mimetic CD3ε variants prevent TCR and CAR signaling. Front Immunol. 15:1392933. doi: 10.3389/fimmu.2024.1392933.

Keller B, Kfir-Erenfeld S, Matusewicz P, Hartl F, Lev A, Lee YN, Simon AJ, Stauber T, Elpeleg O, Somech R, Stepensky P, Minguet S, Schraven B, Warnatz K. 2024. Combined Immunodeficiency Caused by a Novel Nonsense Mutation in LCK. J Clin Immunol. 44(1):4. doi: 10.1007/s10875-023-01614-4.

Hartl FA, Beck-Garcìa E, Woessner NM, Flachsmann LJ, Cárdenas RMV, Brandl SM, Taromi S, Fiala GJ, Morath A, Mishra P, Yousefi OS, Zimmermann J, Hoefflin N, Köhn M, Wöhrl BM, Zeiser R, Schweimer K, Günther S, Schamel WW, Minguet S. 2020. Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function. Nat Immunol. 21(8):902-913. doi: 10.1038/s41590-020-0732-3. Epub 2020 Jul 20.