Post-doctoral Researcher
(Alumni)
Medical Center – University of Freiburg
Department of Medicine II; Gastroenterology, Hepatology, Endocrinology and Infectiology
| 08/2018 – present | PhD student in the lab of Prof. Robert Thimme and Dr. Maike Hofmann, Department of Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectiology, Medical Center - University of Freiburg |
| 01/2018 – 07/2018 | Internship in the lab of Prof. Dr. Paul Klenerman, Nuffield Department of Medicine, University of Oxford, United Kindgom |
| 10/2015 – 10/2017 | M. Sc. in Biology, University of Freiburg, Germany |
| 10/2012 – 09/2015 | B. Sc. in Biology, Technical University Braunschweig, Germany |
Publications
Atcheson, E. , Li, W. , Bliss, C. M., Chinnakannan, S. , Heim, K. , Sharpe, H. , Hutchings, C. , Dietrich, I. , Nguyen, D. , Kapoor, A. , Jarvis, M. A., Klenerman, P. , Barnes, E. and Simmonds, P. 2019. Use of an outbred rat hepacivirus challenge model for design and evaluation of efficacy of different immunisation strategies for HCV. Hepatology. Aug 10. doi: 10.1002/hep.30894. [Epub ahead of print]
Shangqing Yang*, Lu Wang*, Wen Pan, Wibke Bayer, Christine Thoens, Kathrin Heim, Qin Wang, Qing Yu, Jinzhuo Luo, Yanan Liu, Ulf Dittmer, Joerg Timm, Maike Hofmann, Robert Thimme, Xiaoyong Zhang, Hongtao Chen, Hua Wang, Xuemei Feng, Xuecheng Yang, Yinping Lu, Mengji Lu, Dongliang Yang#, Jia Liu#. 2019. MMP2/MMP9-mediated CD100 shedding is crucial for inducing intrahepatic anti-HBV CD8 T cell responses and HBV clearance. J Hepatol 71(4):685-698.
Publications based on CRC1160 funding
Heim K, Sagar, Sogukpinar Ö, Llewellyn-Lacey S, Price DA, Emmerich F, Kraft ARM, Cornberg M, Kielbassa S, Knolle P, Wohlleber D, Bengsch B, Boettler T, Neumann-Haefelin C, Thimme R, Hofmann M. 2024. Attenuated effector T cells are linked to control of chronic HBV infection. Nat Immunol. 25(9):1650-1662. doi: 10.1038/s41590-024-01928-4.
Bosch M, Kallin N, Donakonda S, Zhang JD, Wintersteller H, Hegenbarth S, Heim K, Ramirez C, Fürst A, Lattouf EI, Feuerherd M, Chattopadhyay S, Kumpesa N, Griesser V, Hoflack JC, Siebourg-Polster J, Mogler C, Swadling L, Pallett LJ, Meiser P, Manske K, de Almeida GP, Kosinska AD, Sandu I, Schneider A, Steinbacher V, Teng Y, Schnabel J, Theis F, Gehring AJ, Boonstra A, Janssen HLA, Vandenbosch M, Cuypers E, Öllinger R, Engleitner T, Rad R, Steiger K, Oxenius A, Lo WL, Klepsch V, Baier G, Holzmann B, Maini MK, Heeren R, Murray PJ, Thimme R, Herrmann C, Protzer U, Böttcher JP, Zehn D, Wohlleber D, Lauer GM, Hofmann M, Luangsay S, Knolle PA.2024. A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection. Nature. 631(8022):867-875. doi: 10.1038/s41586-024-07630-7.
Kraemer, A. N., A. L. Schafer, D. T. L. Sprenger, B. Sehnert, J. P. Williams, A. Luo, L. Riechert, Q. Al-Kayyal, H. Dumortier, J. D. Fauny, Z. Winter, K. Heim, M. Hofmann, M. Herrmann, G. Heine, R. E. Voll, and N. Chevalier. 2022. Impact of dietary vitamin D on immunoregulation and disease pathology in lupus-prone NZB/W F1 mice. Front Immunol 13: 933191. doi: 10.3389/fimmu.2022.933191.
Heim, K., B. Binder, Sagar, D. Wieland, N. Hensel, S. Llewellyn-Lacey, E. Gostick, D. A. Price, F. Emmerich, H. Vingerhoet, A. R. M. Kraft, M. Cornberg, T. Boettler, C. Neumann-Haefelin, D. Zehn, B. Bengsch, M. Hofmann, and R. Thimme. 2020. TOX defines the degree of CD8+ T cell dysfunction in distinct phases of chronic HBV infection. Gut. doi: 10.1136/gutjnl-2020-322404. Online ahead of print.
Heim, K., Neumann-Haefelin, R. Thimme, and M. Hofmann. 2019. Heterogeneity of HBV-Specific CD8(+) T-Cell Failure: Implications for Immunotherapy. Front Immunol 10: 2240.
Schuch A, Salimi Alizei E, Heim K, Wieland D, Kiraithe MM, Kemming J, Llewellyn-Lacey S, Sogukpinar Ö, Ni Y, Urban S, Zimmermann P, Nassal M, Emmerich F, Price DA, Bengsch B, Luxenburger H, Neumann-Haefelin C, Hofmann M, Thimme R. 2019. Phenotypic and functional differences of HBV corespecific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load. Gut. 68(5):905-915.
