Post-doctoral Researcher
(Alumni)
Institute for Immunodeficiency
Center for Chronic Immunodeficiency
Medical Center – University of Freiburg
Hermann Herder Str. 11
79104 Freiburg i. Brsg.
Postgraduate Positions
| July 2018 - present | Postdoctoral Research Associate in the lab of Dr. Peter Aichele, Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center - University of Freiburg |
| Oct 2016 - June 2018 | Postdoctoral Research Associate in the lab of Prof. Dr. Gillian Griffiths, Cambridge Institute of Medical research (CIMR), Cambridge, UK |
| Oct 2011 - Oct 2016 | PhD in Immunology, Center for Chronic Immunodeficiency, Medical Center - University of Freiburg |
Miscellaneous (Honors, Awards)
| 2021 | Walter-Hitzig Award (Arbeitsgemeinschaft Pädiatrische Immunologie) |
| Oct 2020 - present | Mentee of the EIRA Mentoring program of the Medical Faculty Freiburg |
link to all publications from S. Ammann: Pubmed
Publications based on CRC1160 funding
Mann J, Runge S, Schell C, Gräwe K, Thoulass G, Lao J, Ammann S, Grün S, König C, Berger SA, Hild B, Aichele P, Rosshart SP, Ehl S. 2024. The Microbiome Modifies Manifestations of Hemophagocytic Lymphohistiocytosis in Perforin-Deficient Mice. Eur J Immunol. 2024 Nov 16:e202451061. doi: 10.1002/eji.202451061.
Kögl T, Chang HF, Staniek J, Chiang SCC, Thoulass G, Lao J, Weißert K, Dettmer-Monaco V, Geiger K, Manna PT, Beziat V, Momenilandi M, Tu SM, Keppler SJ, Pattu V, Wolf P, Kupferschmid L, Tholen S, Covill LE, Ebert K, Straub T, Groß M, Gather R, Engel H, Salzer U, Schell C, Maier S, Lehmberg K, Cornu TI, Pircher H, Shahrooei M, Parvaneh N, Elling R, Rizzi M, Bryceson YT, Ehl S, Aichele P, Ammann S. 2024. Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect. J Exp Med. 221(7):e20221122. doi: 10.1084/jem.20221122.
Dettmer-Monaco V, Weißert K, Ammann S, Monaco G, Lei L, Gräßel L, Rhiel M, Rositzka J, Kaufmann MM, Geiger K, Andrieux G, Lao J, Thoulass G, Schell C, Boerries M, Illert AL, Cornu TI, Ehl S, Aichele P, Cathomen T. 2024. Gene editing of hematopoietic stem cells restores T-cell response in familial hemophagocytic lymphohistiocytosis. J Allergy Clin Immunol. Jan;153(1):243-255.e14. doi: 10.1016/j.jaci.2023.08.003.
Brauer N, Maruta Y, Lisci M, Strege K, Oschlies I, Nakamura H, Böhm S, Lehmberg K, Brandhoff L, Ehl S, Parvaneh N, Klapper W, Fukuda M, Griffiths GM, Hennies HC, Niehues T, Ammann S. 2023. Immunodeficiency with susceptibility to lymphoma with complex genotype affecting energy metabolism (FBP1, ACAD9) and vesicle trafficking (RAB27A). Front Immunol. 14:1151166. doi: 10.3389/fimmu.2023.1151166.
Kemna J, Gout E, Daniau L, Lao J, Weißert K, Ammann S, Kühn R, Richter M, Molenda C, Sporbert A, Zocholl D, Klopfleisch R, Lortat-Jacob H, Aichele P, Kammertoens T, Blankenstein T. 2023. IFNγ binding to extracellular matrix prevents fatal systemic toxicity. Nat Immunol. 24, 414–422. doi.org/10.1038/s41590-023-01420-5
Weissert, K., S. Ammann, T. Kogl, V. Dettmer-Monaco, C. Schell, T. Cathomen, S. Ehl, and P. Aichele. 2022. Adoptive T cell therapy cures mice from active hemophagocytic lymphohistiocytosis (HLH). EMBO Mol Med: e16085. doi: 10.15252/emmm.202216085.
Ohishi Y, Ammann S, Ziaee V, Strege K, Groß M, Amos CV, Shahrooei M, Ashournia P, Razaghian A, Griffiths GM, Ehl S, Fukuda M, Parvaneh N. 2020. Griscelli Syndrome Type 2 Sine Albinism: Unraveling Differential RAB27A Effector Engagement. Front Immunol. 11:612977. doi: 10.3389/fimmu.2020.612977.
Ammann, S., S. Fuchs, L. Martin-Martin, C. N. Castro, B. Spielberger, C. Klemann, R. Elling, M. Heeg, C. Speckmann, I. Hainmann, P. Kaiser-Labusch, G. Horneff, J. Thalhammer, R. G. Bredius, U. Z. Stadt, K. Lehmberg, I. Fuchs, C. von Spee-Mayer, P. Henneke, and S. Ehl. 2020. Functional flow cytometry of monocytes for routine diagnosis of innate primary immunodeficiencies. J Allergy Clin Immunol 145: 434-437 e434.
Klemann C, Camacho-Ordonez N, Yang L, Eskandarian Z, Rojas-Restrepo JL, Frede N, Bulashevska A, Heeg M, Al-Ddafari MS, Premm J, Seidl M, Ammann S, Sherkat R, Radhakrishnan N, Warnatz K, Unger S, Kobbe R, Hüfner A, Leahy TR, Ip W, Burns SO, Fliegauf M, Grimbacher B. 2019. Clinical and Immunological Phenotype of Patients With Primary Immunodeficiency Due to Damaging Mutations in NFKB2. Front Immunol. 10:297.
Heeg, M., S. Ammann, C. Klemann, M. Panning, V. Falcone, H. Hengel, K. Lehmberg, U. Zur Stadt, K. Wustrau, G. Janka, and Ehl. 2018. Is an infectious trigger always required for primary hemophagocytic lymphohistiocytosis? Lessons from in utero and neonatal disease. Pediatr Blood Cancer 65: e27344.
Weiss ES, Girard-Guyonvarc’h C, Holzinger D, de Jesus AA, Tariq Z, Picarsic J,Schiffrin EJ, Foell D, Grom AA, Ammann S, Ehl S, Hoshino T, Goldbach-Mansky R, Gabay C, Canna SW. “Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome.” Blood.
2018Mar29;131(13):1442-1455. doi: 10.1182/blood-2017-12-820852. Epub 2018 Jan 11
Ammann S, Lehmberg K, Zur Stadt U, Klemann C, Bode SFN, Speckmann C, Janka G, Wustrau K, Rakhmanov M, Fuchs I, Hennies HC, Ehl S; HLH study of the GPOH. 2017. Effective Immunological Guidance of Genetic Analyses Including Exome Sequencing in Patients Evaluated for Hemophagocytic Lymphohistiocytosis. J Clin Immunol. 37(8):770-780.
Klemann C, Ammann S, Heizmann M, Fuchs S, Bode SF, Heeg M, Fuchs H, Lehmberg K, Zur Stadt U, Roll C, Vraetz T, Speckmann C, Lorenz MR, Schwarz K, Rohr J, Feske S, Ehl S. 2017. Hemophagocytic lymphohistiocytosis as presenting manifestation of profound combined immunodeficiency due to an ORAI1 mutation. J Allergy Clin Immunol. 140(6):1721-1724.
Chiang SCC, Wood SM, Tesi B, Akar HH, Al-Herz W, Ammann S, Belen FB, Caliskan U, Kaya Z, Lehmberg K, Patiroglu T, Tokgoz H, Ünüvar A, Introne WJ, Henter JI, Nordenskjöld M, Ljunggren HG, Meeths M, Ehl S, Krzewski K, Bryceson YT. 2017. Differences in Granule Morphology yet Equally Impaired Exocytosis among Cytotoxic T Cells and NK Cells from Chediak-Higashi Syndrome Patients. Front Immunol. 8:426.
Ammann S, Lehmberg K, Zur Stadt U, Janka G, Rensing-Ehl A, Klemann C, Heeg M, Bode S, Fuchs I, Ehl S; HLH study of the GPOH. 2017. Primary and secondary hemophagocytic lymphohistiocytosis have different patterns of T-cell activation, differentiation and repertoire. Eur J Immunol. 47(2):364-373.
Hartz, B., R. Marsh, K. Rao, J. I. Henter, M. Jordan, L. Filipovich, P. Bader, R. Beier, B. Burkhardt, R. Meisel, A. Schulz, B. Winkler, M. H. Albert, J. Greil, G. Karasu, W. Woessmann, S. Corbacioglu, B. Gruhn, W. Holter, J. S. Kuhl, P. Lang, M. G. Seidel, P. Veys, A. Lofstedt, S. Ammann, Ehl, G. Janka, I. Muller, and K. Lehmberg. 2016. The minimum required level of donor chimerism in hereditary hemophagocytic lymphohistiocytosis. Blood 127: 3281-3290.
Ammann S, Schulz A, Krägeloh-Mann I, Dieckmann NM, Niethammer K, Fuchs S, Eckl KM, Plank R, Werner R, Altmüller J, Thiele H, Nürnberg P, Bank J, Strauss A, von Bernuth H, Zur Stadt U, Grieve S, Griffiths GM, Lehmberg K, Hennies HC, Ehl S. 2016. Mutations in AP3D1 associated with immunodeficiency and seizures define a new type of Hermansky-Pudlak syndrome. Blood. 127(8):997-1006.
