Jan 25, 2024
The findings of the CRC 1160 member, Susana Minguet (B01), address an important question and provide some clear directions for the use of the λ-chain locus. In particular, it highlights the role of Kidins220 in prolonging B cell survival to extend the time available for the λ light chain locus to open for VJ recombination. It is also shown that prolonged survival alone is not sufficient to enhance λ light chain recombination, which is an important contribution to our understanding of the B cell repertoire.
The findings have been published in eLife and are available here.
