Edward Pearce

Prof. Dr.
Alumni

Max Planck Institute of Immunobiology and Epigenetics
Department of Immunometabolism

Stübeweg 51
79108 Freiburg i. Brsg.

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link to all publications from E. Pearce: Pubmed

Publications based on CRC1160 funding

Villa M, Sanin DE, Apostolova P, Corrado M, Kabat AM, Cristinzio C, Regina A, Carrizo GE, Rana N, Stanczak MA, Baixauli F, Grzes KM, Cupovic J, Solagna F, Hackl A, Globig AM, Hässler F, Puleston DJ, Kelly B, Cabezas-Wallscheid N, Hasselblatt P, Bengsch B, Zeiser R, Sagar, Buescher JM, Pearce EJ, Pearce EL. 2023. Prostaglandin E 2 controls the metabolic adaptation of T cells to the intestinal microenvironment. bioRxiv. Mar 15:2023.03.13.532431. doi: 10.1101/2023.03.13.532431.

Ho, J., D. Schmidt, T. Lowinus, J. Ryoo, E. P. Dopfer, N. Gonzalo Nunez, S. Costa-Pereira, C. Toffalori, M. Punta, V. Fetsch, T. Wertheimer, M. C. Rittmann, L. M. Braun, M. Follo, C. Briere, J. M. Vinnakota, M. Langenbach, F. Koppers, K. Shoumariyeh, H. Engel, T. Ruckert, M. Marklin, S. Holzmayer, A. L. Illert, F. Magon, G. Andrieux, S. Duquesne, D. Pfeifer, J. Staniek, M. Rizzi, C. Miething, N. Kohler, J. Duyster, H. D. Menssen, M. Boerries, J. M. Buescher, N. Cabezas-Wallscheid, B. R. Blazar, P. Apostolova, L. Vago, E. L. Pearce, B. Becher, and R. Zeiser. 2022. Targeting MDM2 enhances antileukemia immunity after allogeneic transplantation via MHC-II and TRAIL-R1/2 upregulation. Blood 140: 1167-1181. doi: 10.1182/blood.2022016082.

Grzes KM, Sanin DE, Kabat AM, Stanczak MA, Edwards-Hicks J, Matsushita M, Hackl A, Hässler F, Knoke K, Zahalka S, Villa M, Kofler DM, Voll RE, Zigrino P, Fabri M, Pearce EL, Pearce EJ. 2021. Plasmacytoid dendritic cell activation is dependent on coordinated expression of distinct amino acid transporters. Immunity. 54(11):2514-2530.e7. doi: 10.1016/j.immuni.2021.10.009. Epub 2021 Oct 29.

O’Sullivan D, Stanczak MA, Villa M, Uhl FM, Corrado M, Klein Geltink RI, Sanin DE, Apostolova P, Rana N, Edwards-Hicks J, Grzes KM, Kabat AM, Kyle RL, Fabri M, Curtis JD, Buck MD, Patterson AE, Regina A, Field CS, Baixauli F, Puleston DJ, Pearce EJ, Zeiser R, Pearce EL. 2021. Fever supports CD8+ effector T cell responses by promoting mitochondrial translation. Proc Natl Acad Sci U S A. 118(25):e2023752118.

Klein Geltink, R. I., J. Edwards-Hicks, P. Apostolova, D. O’Sullivan, D. E. Sanin, A. E. Patterson, D. J. Puleston, N. A. M. Ligthart, J. M. Buescher, K. M. Grzes, A. M. Kabat, M. Stanczak, J. D. Curtis, F. Hassler, F. M. Uhl, M. Fabri, R. Zeiser, E. J. Pearce, and E. L.

 

 

Pearce. 2020. Metabolic conditioning of CD8(+) effector T cells for adoptive cell therapy. Nat Metab 2: 703-716.

van Teijlingen Bakker, N., and E. J. Pearce. 2020. Cell-intrinsic metabolic regulation of mononuclear phagocyte activation: Findings from the tip of the iceberg. Immunol Rev 295: 54-67

Qiu, J., M. Villa, D. E. Sanin, M. D. Buck, D. O’Sullivan, R. Ching, M. Matsushita, K. M. Grzes, F. Winkler, C. H. Chang, J. D. Curtis, R. L. Kyle, N. Van Teijlingen Bakker, M. Corrado, F. Haessler, F. Alfei, J. Edwards-Hicks, L. B. Maggi, Jr., D. Zehn, T. Egawa, B. Bengsch, R. I. Klein Geltink, T. Jenuwein, E. J. Pearce, and E. L. Pearce. 2019. Acetate Promotes T Cell Effector Function during Glucose Restriction. Cell Rep 27: 2063-2074 e2065.