Olaf Groß

Saller BS, Wöhrle S, Fischer L, Dufossez C, Ingerl IL, Kessler S, Mateo-Tortola M, Gorka O, Lange F, Cheng Y, Neuwirt E, Marada A, Koentges C, Urban C, Aktories P, Reuther P, Giese S, Kirschnek S, Mayer C, Pilic J, Falquez-Medina H, Oelgeklaus A, Deepagan VG, Shojaee F, Zimmermann JA, Weber D, Tai YH, Crois A, Ciminski K, Peyronnet R, Brandenburg KS, Wu G, Baumeister R, Heimbucher T, Rizzi M, Riedel D, Helmstädter M, Buescher J, Neumann K, Misgeld T, Kerschensteiner M, Walentek P, Kreutz C, Maurer U, Rambold AS, Vince JE, Edlich F, Malli R, Häcker G, Kierdorf K, Meisinger C, Köttgen A, Jakobs S, Weber ANR, Schwemmle M, Groß CJ, Groß O. 2024. Acute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activation. Immunity. S1074-7613(24)00492-8. doi: 10.1016/j.immuni.2024.10.012.

Vogele D, Wöhrle S, Saller BS, Fröhlich K, Barta BA, Cosenza-Contreras M, Groß O, Schilling O. 2024. Size exclusion chromatography based proteomic and degradomic profiling of inflammasome-activated, murine bone marrow-derived dendritic cells highlights complex retention and release of cleavage products. Mol Omics. 2024 Oct 28;20(9):595-610. doi: 10.1039/d4mo00163j.

Wertman RS, Yost W, Herrmann BI, Bourne CM, Sorobetea D, Go CK, Saller BS, Groß O, Scott P, Rongvaux A, Taabazuing CY, Brodsky IE. 2024. Distinct sequential death complexes regulate pyroptosis and IL-1β release in response to Yersinia blockade of immune signaling. Sci Adv. 10(30):eadl3629. doi: 10.1126/sciadv.adl3629.

Colcerasa A, Friedrich F, Melesina J, Moser P, Vogelmann A, Tzortzoglou P, Neuwirt E, Sum M, Robaa D, Zhang L, Ramos-Morales E, Romier C, Einsle O, Metzger E, Schüle R, Groß O, Sippl W, Jung M. 2024. Structure-Activity Studies of 1,2,4-Oxadiazoles for the Inhibition of the NAD+-Dependent Lysine Deacylase Sirtuin 2. J Med Chem. 67(12):10076-10095. doi: 10.1021/acs.jmedchem.4c00229.

Hersperger F, Meyring T, Weber P, Chhatbar C, Monaco G, Dionne MS, Paeschke K, Prinz M, Groß O, Classen AK, Kierdorf K. 2024. DNA damage signaling in Drosophila macrophages modulates systemic cytokine levels in response to oxidative stress. Elife. 2024 Jan 8;12:RP86700. doi: 10.7554/eLife.86700.

Caceres L, Abogunloko T, Malchow S, Ehret F, Merz J, Li X, Sol Mitre L, Magnani N, Tasat D, Mwinyella T, Spiga L, Suchanek D, Fischer L, Gorka O, Colin Gissler M, Hilgendorf I, Stachon P, Rog-Zielinska E, Groß O, Westermann D, Evelson P, Wolf D, Marchini T. 2023. Molecular mechanisms underlying NLRP3 inflammasome activation and IL-1β production in air pollution fine particulate matter (PM2.5)-primed macrophages. Environ Pollut. 2023 Nov 22;341:122997. doi: 10.1016/j.envpol.2023.122997.

Winkler F, Hipp AV, Ramirez C, Martin B, Villa M, Neuwirt E, Gorka O, Aerssens J, Johansson SE, Rana N, Llewellyn-Lacey S, Price DA, Panning M, Groß O, Pearce EL, Hermann CM, Schumann K, Hannibal L, Neumann-Haefelin C, Boettler T, Knolle P, Hofmann M, Wohlleber D, Thimme R, Bengsch B. 2023. Enolase represents a metabolic checkpoint controlling the differential exhaustion programmes of hepatitis virus-specific CD8+ T cells. Gut. 72(10):1971-1984. doi: 10.1136/gutjnl-2022-328734.

Eisenbeis, V. B., D. Qiu, O. Gorka, L. Strotmann, G. Liu, I. Prucker, X. B. Su, M. S. C. Wilson, K. Ritter, C. Loenarz, Gross, A. Saiardi, and H. J. Jessen. 2023. beta-lapachone regulates mammalian inositol pyrophosphate levels in an NQO1- and oxygen-dependent manner. Proc Natl Acad Sci U S A 120: e2306868120.

Griewahn L, Müller-Foxworth M, Peintner L, Wissler M, Weiss M, Brauns-Schubert P, Massoumi R, Borner C, Groß O, Yabal M, Charvet C, Maurer U. 2023. SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD. Cell Rep. 42(1):111961. doi: 10.1016/j.celrep.2022.111961.

Rapp, J., M. Jung, R. F. U. Klar, J. Wolf, J. Arnold, O. Gorka, O. Gross, C. Lange, H. Agostini, G. Schlunck, and F. Bucher. 2022. STAT3 signaling induced by IL-6 family cytokines modulates angiogenesis. J Cell Sci. :jcs.260182. doi: 10.1242/jcs.260182.

Carvalho LAR, Ross B, Fehr L, Bolgi O, Wöhrle S, Lum KM, Podlesainski D, Vieira AC, Kiefersauer R, Félix R, Rodrigues T, Lucas SD, Groß O, Geiss-Friedlander R, Cravatt BF, Huber R, Kaiser M, Moreira R. 2022. Chemoproteomics-Enabled Identification of 4-Oxo-β-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9. Angew Chem Int Ed Engl. 61(47):e202210498. doi: 10.1002/anie.202210498.

Gruninger, P. K., F. Uhl, H. Herzog, G. Gentile, M. Andrade-Martinez, T. Schmidt, K. Han, D. W. Morgens, M. C. Bassik, M. L. Cleary, O. Gorka, R. Zeiser, O. Gross, and J. Duque-Afonso. 2022. Functional characterization of the PI3K/AKT/MTOR signaling pathway for targeted therapy in B-precursor acute lymphoblastic leukemia. Cancer Gene Ther. pii: 10.1038/s41417-022-00491-0. doi: 10.1038/s41417-022-00491-0.

Carvalho, L. A. R., B. Ross, L. Fehr, O. Bolgi, S. Wohrle, K. M. Lum, D. Podlesainski, A. C. Vieira, R. Kiefersauer, R. Felix, T. Rodrigues, S. D. Lucas, O. Gross, R. Geiss-Friedlander, B. F. Cravatt, R. Huber, M. Kaiser, and R. Moreira. 2022. Chemoproteomics-Enabled Identification of 4-Oxo-beta-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9. Angew Chem Int Ed Engl 61: e202210498. doi: 10.1002/anie.202210498.

Aktories, P., P. Petry, P. Glatz, G. Andrieux, A. Oschwald, H. Botterer, O. Gorka, D. Erny, M. Boerries, P. Henneke, O. Gross, M. Prinz, and K. Kierdorf. 2022. An improved organotypic cell culture system to study tissue-resident macrophages ex vivo. Cell Rep Methods 2: 100260. doi: 10.1016/j.crmeth.2022.100260.

Kolter J, Henneke P, Groß O, Kierdorf K, Prinz M, Graf L, Schwemmle M. 2022. Paradoxical immunodeficiencies-When failures of innate immunity cause immunopathology. Eur J Immunol. First published: 2022 May 12. doi: 10.1002/eji.202149531.

Vogelmann A, Schiedel M, Wössner N, Merz A, Herp D, Hammelmann S, Colcerasa A, Komaniecki G, Hong JY, Sum M, Metzger E, Neuwirt E, Zhang L, Einsle O, Groß O, Schüle R, Lin H, Sippl W, Jung M. 2022. Development of a NanoBRET assay to validate inhibitors of Sirt2-mediated lysine deacetylation and defatty-acylation that block prostate cancer cell migration. RSC Chem Biol 3(4):468-485. doi: 10.1039/d1cb00244a.

Merz J, Nettesheim A, von Garlen S, Albrecht P, Saller BS, Engelmann J, Hertle L, Schäfer I, Dimanski D, König S, Karnbrock L, Bulatova K, Peikert A, Hoppe N, Hilgendorf I, von Zur Mühlen C, Wolf D, Groß O, Bode C, Zirlik A, Stachon P. 2021. Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile. Purinergic Signal. 17(3):481-492.

Hatscher L, Lehmann CHK, Purbojo A, Onderka C, Liang C, Hartmann A, Cesnjevar R, Bruns H, Gross O, Nimmerjahn F, Ivanović-Burmazović I, Kunz M, Heger L, Dudziak D. 2021. Select hyperactivating NLRP3 ligands enhance the TH1- and TH17-inducing potential of human type 2 conventional dendritic cells. Sci Signal. 14(680):eabe1757.

Neuwirt E, Gorka O, Saller BS, Groß CJ, Madl T, Groß O. 2021. NLRP3 as a sensor of metabolism gone awry. Curr Opin Biotechnol. 68:300-309.

Emig, R., W. Knodt, M. J. Krussig, C. M. Zgierski-Johnston, O. Gorka, O. Gross, P. Kohl, U. Ravens, and R. Peyronnet. 2021. Piezo1 Channels Contribute to the Regulation of Human Atrial Fibroblast Mechanical Properties and Matrix Stiffness Sensing. Cells 10: 663.

Bauer C, Quante M, Breunis WB, Regina C, Schneider M, Andrieux G, Gorka O, Groß O, Boerries M, Kammerer B, Hettmer S. 2021. Lack of Electron Acceptors Contributes to Redox Stress and Growth Arrest in Asparagine-Starved Sarcoma Cells. Cancers (Basel). 13(3):412.

Hamarsheh, S., O. Gross, T. Brummer, and R. Zeiser. 2020. Immune modulatory effects of oncogenic KRAS in cancer. Nat Commun 11: 5439.

Uhl, F. M., S. Chen, D. O’Sullivan, J. Edwards-Hicks, G. Richter, E. Haring, G. Andrieux, S. Halbach, P. Apostolova, J. Buscher, S. Duquesne, W. Melchinger, B. Sauer, K. Shoumariyeh, A. Schmitt-Graeff, M. Kreutz, M. Lubbert, J. Duyster, T. Brummer, M. Boerries, T. Madl, B. R. Blazar, O. Gross, E. L. Pearce, and R. Zeiser. 2020. Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans. Sci Transl Med 12:eabb8969. doi: 10.1126/scitranslmed.abb8969.

Hamarsheh, S., L. Osswald, B. S. Saller, S. Unger, D. De Feo, J. M. Vinnakota, M. Konantz, F. M. Uhl, H. Becker, M. Lubbert, K. Shoumariyeh, C. Schurch, G. Andrieux, N. Venhoff, A. Schmitt-Graeff, S. Duquesne, D. Pfeifer, M. A. Cooper, C. Lengerke, M. Boerries, J. Duyster, C. M. Niemeyer, M. Erlacher, B. R. Blazar, B. Becher, O. Gross, T. Brummer, and R. Zeiser. 2020. Oncogenic Kras(G12D) causes myeloproliferation via NLRP3 inflammasome activation. Nat Commun 11: 1659.