Project Summary
C02, Groß, works on cytokine-mediated impairment of macrophage homeostasis resulting in inflammatory consequences. The focus will be on the consequences of IFNγ and GM-CSF-induced signaling on macrophage activity. In addition to effects on the NLRP3 inflammasome, the project more broadly elucidates the impact on macrophage metabolism and the epigenetic landscape in general, using unbiased approaches. The role of these mechanisms in SARS-CoV-2 immunopathology is studied in close collaboration with C01.
